Ziti Pepperoni Casserole Recipe

This cheesy, crowd-pleasing Ziti Pepperoni Casserole is a family favorite! So easy, even your kids can help make it. Perfect for a weeknight dinner or a fun weekend activity. Enjoy it fresh from the oven, or make ahead and freeze for future meals. This recipe offers a convenient microwave option for summer, and includes detailed freezing and reheating instructions. Substitute ricotta cheese for cottage cheese if desired. Get ready for cheesy goodness!

Prep Time 20 mins
Cook Time 60 mins
Calories 658.7 kcal
Protein 69g
Rating Be the first
Ziti Pepperoni Casserole 42

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Forktionary editorial kitchen team

The Forktionary Kitchen Team

Adapted from Food.com, then tested & standardized by Forktionary.

Ingredients for Ziti Pepperoni Casserole

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How to Make Ziti Pepperoni Casserole

  1. Preheat oven to 375°F (190°C).
  2. Set aside 1 cup of shredded mozzarella and 1/2 cup of parmesan cheese for topping.
  3. In a large bowl, combine 1 pound ziti pasta (cooked al dente), 1 (28 ounce) can crushed tomatoes, 1 (15 ounce) can tomato sauce, 1 teaspoon dried oregano, 1/2 teaspoon garlic powder, 1/4 teaspoon black pepper, 1 cup cottage cheese (or ricotta cheese), 2 cups shredded mozzarella cheese, 1 cup shredded parmesan cheese, and 1 cup pepperoni slices.
  4. Mix all ingredients thoroughly until well combined.
  5. Pour the mixture into a greased 13x9 inch baking dish.
  6. Sprinkle the reserved mozzarella and parmesan cheese evenly over the top.
  7. Bake for 40 minutes, or until golden brown and bubbly.
  8. **To Freeze:** Let the casserole cool completely. Cover the baking dish tightly with foil and freeze for up to 3 months.
  9. **To Reheat from Frozen:** Thaw overnight in the refrigerator. Preheat oven to 350°F (175°C). Cover the dish with foil and bake for 20 minutes. Remove foil and bake for an additional 10-15 minutes, or until heated through and bubbly.

Nutrition Information (Approximate per serving)

Sodium

53 g

Sugar

35g

Fat

77g

Carbs

17g

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Frequently Asked Questions

How long does it take to make Ziti Pepperoni Casserole?

Ziti Pepperoni Casserole takes about 80 minutes from start to finish — roughly 20 minutes to prepare and 60 minutes to cook.

How many calories are in Ziti Pepperoni Casserole?

Ziti Pepperoni Casserole has approximately 658.7 calories per serving, with about 69 g protein, 17 g carbohydrates and 50 g fat.

What ingredients do I need for Ziti Pepperoni Casserole?

The key ingredients for Ziti Pepperoni Casserole are Ziti Pasta, Spaghetti Sauce, Mozzarella Cheese, Cheddar Cheese, Pepperoni, Cottage Cheese. See the full list with measurements above.

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