Buffalo Meatloaf Recipe

This Buffalo Meatloaf recipe is a crowd-pleaser! Enjoy a juicy, flavorful meatloaf bursting with delicious buffalo-inspired notes. Made with ground buffalo (or easily substituted with ground beef!), this recipe is perfect for a weeknight dinner or a special occasion. So good, you'll likely have no leftovers – but if you do, it makes amazing sandwiches the next day! We often make extra sauce and heat it in the microwave for an extra layer of flavor.

Prep Time 20 mins
Cook Time 70 mins
Calories 207.6 kcal
Protein 53g
Rating Be the first
Buffalo Meatloaf 41

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Forktionary editorial kitchen team

The Forktionary Kitchen Team

Adapted from Food.com, then tested & standardized by Forktionary.

Ingredients for Buffalo Meatloaf

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How to Make Buffalo Meatloaf

  1. Preheat oven to 350°F (175°C).
  2. Soak 1 cup breadcrumbs in ½ cup milk until the milk is completely absorbed (about 5 minutes).
  3. In a large bowl, lightly beat 2 large eggs.
  4. Add the soaked breadcrumb mixture to the eggs and mix well.
  5. Add 2 lbs ground buffalo (or beef), 1 medium onion (finely diced), 1 ½ tsp salt, 1 tsp black pepper, and ½ tsp sage. Gently combine until just mixed; do not overmix.
  6. Grease a 9x5 inch loaf pan.
  7. Pack the meatloaf mixture lightly into the prepared loaf pan.
  8. In a small bowl, whisk together ¼ cup brown sugar, ½ cup ketchup, ¼ tsp nutmeg, and 1 tsp dry mustard.
  9. Spread the sauce evenly over the top of the meatloaf.
  10. Bake for 60-70 minutes, or until the internal temperature reaches 160°F (71°C).
  11. Let the meatloaf rest for 10 minutes before slicing and serving. Drain off any excess liquid before serving.

Nutrition Information (Approximate per serving)

Sodium

21 g

Sugar

29g

Fat

8g

Carbs

4g

Frequently Asked Questions

How long does it take to make Buffalo Meatloaf?

Buffalo Meatloaf takes about 90 minutes from start to finish — roughly 20 minutes to prepare and 70 minutes to cook.

How many calories are in Buffalo Meatloaf?

Buffalo Meatloaf has approximately 207.6 calories per serving, with about 53 g protein, 4 g carbohydrates and 6 g fat.

What ingredients do I need for Buffalo Meatloaf?

The key ingredients for Buffalo Meatloaf are Dry Breadcrumbs, Milk, Ground Buffalo Meat, Eggs, Diced Onion, Salt. See the full list with measurements above.

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