Italian Stuffed Meatloaf Recipe

Elevate your weeknight meal with this incredibly flavorful Italian Stuffed Meatloaf! A juicy blend of sirloin and turkey is generously stuffed with creamy cheese, vibrant spinach, and sweet roasted red peppers, creating a moist and satisfying centerpiece for any dinner table. This recipe is perfect for meal prepping – freeze for up to 3 months and reheat easily! Serve with our suggested side of frozen Italian green beans and whole wheat pasta for a complete and healthy meal.

Prep Time 20 mins

Cook Time 60 mins

Calories 411.1 kcal

Protein 69g

Rating Be the first

Recipe Actions

Share this recipe:

Recipe Author

The Forktionary Kitchen Team

Adapted from Food.com, then tested & standardized by Forktionary.

Ingredients for Italian Stuffed Meatloaf

1.5 lbs ground sirloin
1 large egg
1/2 cup tomato juice
1 tsp salt, 1/2 tsp black pepper
2 cloves minced garlic
1 tbsp dried oregano
1/2 cup finely chopped onion
1 cup shredded mozzarella cheese
1 (10 ounce) package frozen spinach, thawed and squeezed dry
1/2 cup roasted red peppers, chopped
.5 lbs ground turkey
cooking spray, as needed
spaghetti sauce, for serving (optional)
frozen Italian green beans, for serving
whole wheat pasta, for serving

Cook Smarter with Sous, Your Kitchen Companion

Missing an ingredient for this Italian Stuffed Meatloaf? Need a perfect wine pairing or a healthy side dish idea? Don't guess—ask Sous! Your AI-powered sous-chef is ready to help you swap ingredients, adjust serving sizes, and discover flavor tips in seconds.

How to Make Italian Stuffed Meatloaf

Preheat oven to 350°F (175°C).
In a large bowl, gently combine 1.5 lbs ground sirloin, 0.5 lbs ground turkey, 1 large egg, 1/2 cup tomato juice, 1 tsp salt, 1/2 tsp black pepper, 2 cloves minced garlic, 1 tbsp dried oregano, and 1/2 cup finely chopped onion.
Spray a 9x5x3 inch loaf pan with cooking spray. Place half of the meat mixture into the prepared pan.
Layer 1 cup shredded mozzarella cheese, 1 cup chopped fresh spinach, and 1/2 cup roasted red peppers over the meat mixture.
Top with the remaining meat mixture, ensuring it's evenly distributed.
Bake for 60 minutes, or until the internal temperature reaches 160°F (71°C).
Let the meatloaf cool completely to room temperature before wrapping tightly in plastic wrap and aluminum foil.
Freeze for up to 3 months. To thaw, refrigerate overnight.
Reheat frozen meatloaf in a 350°F (175°C) oven for 20-30 minutes, or until heated through.
Alternatively, slice and reheat individual portions in the microwave.
Optional: Top with a dollop of your favorite spaghetti sauce before serving.
Serve with frozen Italian green beans and/or whole wheat pasta.

Nutrition Information (Approximate per serving)

Sodium

13 g

Sugar

12g

Fat

58g

Carbs

Recipe Categories (Choose a category and find related recipes!)

Main Courses Main Dish / Dinner Side Dishes Poultry Turkey Recipes Beef & Red Meat Ground Beef Recipes European Italian American Healthy Baking

Recipe Tags (Choose a tag and find related recipes!)

60 Minutes Or Less Time To Make Course Main Ingredient Preparation Very Low Carbs Main Dish Beef Dietary Low Sodium Low Carb Ground Beef Low In Something Meat

Frequently Asked Questions

How long does it take to make Italian Stuffed Meatloaf?

Italian Stuffed Meatloaf takes about 80 minutes from start to finish — roughly 20 minutes to prepare and 60 minutes to cook.

How many calories are in Italian Stuffed Meatloaf?

Italian Stuffed Meatloaf has approximately 411.1 calories per serving, with about 69 g protein, 1 g carbohydrates and 41 g fat.

What ingredients do I need for Italian Stuffed Meatloaf?

The key ingredients for Italian Stuffed Meatloaf are Ground Sirloin, Egg White, Tomato Juice, Salt And Pepper, Garlic, Dried Oregano Leaves. See the full list with measurements above.